According to a new study Human heart muscle, cells show changes in the way they operate in space. Exposure to microgravity altered the expression of thousands of genes, but largely normal patterns of gene expression reappeared within 10 days after returning to the Earth.
Microgravity is an environment that impacts the overall effect on the human body. Spaceflight induces physiological changes in cardiac function, including reduced heart rate, lowered arterial pressure, and increased cardiac output.
Steps involved in the researchers hand his collaborators studied human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). They generated hiPSC lines from three individuals by reprogramming blood cells and then differentiated them into hiPSC-CMs.
It is the first to use human induced pluripotent stem cells to study the effects of spaceflight on human heart function said Joseph C Wu of Stanford University School of Medicine, USA. Past studies have shown that spaceflight induces physiological changes in cardiac function, including reduced heart rate, lowered arterial pressure, and increased cardiac output.
These results showed that 2,635 genes were differentially expressed among flight, post-flight, and ground control samples Gene pathways related to mitochondrial function were expressed more in space-flown hiPSC-CMs
A comparison of the samples revealed that hiPSC-CMs adopt a unique gene expression pattern during spaceflight, which reverts to one that is similar to ground side controls upon return to normal gravity, according to the researchers.
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